Product
소개
SiliaBond for Organic Synthesis 소개 및 선택 가이드
Discover How our Reagents & Oxidants Can Optimize your Synthesis
Increasingly, the use of heterogeneous reagents in organic synthesis and chemical production is growing in importance. This technology is completely in line with the industries seeking improved sustainability and reduced ecological footprint. This strong trend is directly derived from the inherent benefits offered by silica-based heterogeneous reagents & oxidants:
• Extremely easy product / API isolation and purification (simple & quick filtration of the heterogeneous support)
• Eliminates or strongly reduces the need for laborious purifications
• No leaching of silica or catalyst and no cross contamination
• Highly suitable for either batch or continuous flow applications
• Convenient for high throughput medicinal & discovery chemistry
• Improved reactivity & selectivity over homogeneous reagents / catalyst
• Compares very favourably to polymer-based reagents: no swelling, thermally stable, more easily scalabe, faster kinetics, compatible with all solvents
and mechanically stable.
Here are a selection of reactions that can be done using our reagents and oxidants:
SiliaBond Reagents & Oxidants 선택 가이드
Typical Reaction | Best SiliaBond Reagent or Oxidant / SiliaCat SiliaCat Catalyst |
---|---|
Acylation / Esterification | |
Alkylation / Etherification | |
Amide Coupling (with acids, acid chlorides and amines) | |
Catalytic Hydrogenation | |
Coupling Reactions Buchwald Amination, Heck, Kumada, Negishi, Sonogashira, Stille & Suzuki Couplings and more... |
|
Deprotection of Aromatic Ether | |
Ether Formation | |
Fmoc, Bsmoc Deprotection of Amino Acid | |
Friedel-Crafts Alkylation | |
Fries-Speier Esterification | |
Knoevenagel Condensation | |
Michael Addition | |
Nitro-Aldol (or Henry) Reaction | |
Oxidation (Alcohols to acids) | |
Oxidation (Alcohols to ketones / aldehydes) | |
Reduction (Reductive Amination, Alkylation, etc.) |
|
Sulfonamide Synthesis | |
Tosylate Formation | |
Urea Synthesis | |
Williamson Ether Synthesis |